![]() The burn areas should be covered with SILVADENE Cream 1% at all times. The burn wounds are then cleansed and debrided, and SILVADENE Cream 1% (silver sulfadiazine) is applied under sterile conditions. Prompt institution of appropriate regimens for care of the burned patient is of prime importance and includes the control of shock and pain. However, reduction in bacterial colonization has caused delayed separation, in some cases necessitating escharotomy in order to prevent contracture. Reduction in bacterial growth after application of topical antibacterial agents has been reported to permit spontaneous healing of deep partial-thickness burns by preventing conversion of the partial thickness to full thickness by sepsis. Other infrequently occurring events include skin necrosis, erythema multiforme, skin discoloration, burning sensation, rashes, and interstitial nephritis. An increased incidence of leukopenia has been reported in patients treated concurrently with cimetidine. Recovery is not influenced by continuation of silver sulfadiazine therapy. Rebound to normal leukocyte levels follows onset within 2 to 3 days. Maximal white blood cell depression occurs within 2 to 4 days of initiation of therapy. 1,2,3 Leukopenia associated with silver sulfadiazine administration is primarily characterized by decreased neutrophil count. Several cases of transient leukopenia have been reported in patients receiving silver sulfadiazine therapy. The use of SILVADENE Cream 1% (silver sulfadiazine) in some cases of glucose-6-phosphate dehydrogenase-deficient individuals may be hazardous, as hemolysis may occur. However, the incidence of clinically reported fungal superinfection is low. If allergic reactions attributable to treatment with silver sulfadiazine occur, continuation of therapy must be weighed against the potential hazards of the particular allergic reaction.įungal proliferation in and below the eschar may occur. There is potential cross-sensitivity between silver sulfadiazine and other sulfonamides. Some of the reactions, which have been associated with sulfonamides, are as follows: blood dyscrasias including agranulocytosis, aplastic anemia, thrombocytopenia, leukopenia, and hemolytic anemia dermatologic and allergic reactions, including life-threatening cutaneous reactions gastrointestinal reactions hepatitis and hepatocellular necrosis CNS reactions and toxic nephrosis. Although few have been reported, it is possible that any adverse reaction associated with sulfonamides may occur. Silver sulfadiazine is not a carbonic anhydrase inhibitor and may be useful in situations where such agents are contraindicated.Ībsorption of silver sulfadiazine varies depending upon the percent of body surface area and the extent of the tissue damage. Breast-feeding is therefore not suggested in infants with these problems while using this medicine.Results of In Vitro Testing with SILVADENE ® Cream 1% (silver sulfadiazine) Concentration of Silver Sulfadiazine Number of Sensitive Strains/Total Number of Strains Tested Genus & Species ![]() Similar medications, on the other hand, enter into breast milk and may affect breastfeeding infants who are unwell, premature, less than 2 months old, or have certain diseases (such as jaundice, high blood levels of bilirubin, G6PD deficiency). It is uncertain whether this medicine is secreted in breast milk. Because of the risk of harm to the unborn baby, this medication should not be used close to the expected delivery date. This medication should be used only when clearly necessary during pregnancy. Side effects associated with this medication include pain, burning, itching, unusual bleeding or bruising, fever, sore throat, yellowing of the skin or eyes, and blood in the urine. Some medications which can have interaction with this drug include cimetidine, and skin products containing Sodium Sulfacetamide, enzyme products used to break down and remove the dead skin from burns and wounds (which includes collagenase, papain, trypsin).Īn inactive factor in a few manufacturers of this medication (Propylene Glycol) can be absorbed and can interfere with laboratory tests, potentially causing false test results. Do not use more or less of it, or use it more frequently than your doctor has prescribed. It is typically applied topically, once or twice daily. ![]() This pharmaceutical medicine is available as a cream. This pharmaceutical medicine is used in conjunction with other medications to aid in the prevention and treatment of wound infections in patients with severe burns. It belongs to the class of drug known as a sulfa antibiotic. Sulfadiazine Silver is sold under the brand name “Silvadene”, “SSD Cream”, and “Thermazene”. ![]()
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